DeMauro, Sara B.D'Agostino, Jo AnnBann, CarlaBernbaum, JudyGerdes, MarshaBell, Edward F.Carlo, Waldemar A.D'Angio, CarlDas, AbhikHiggins, RosemaryHintz, Susan R.Laptook, Abbot R.Natarajan, GirijaNelin, LeifPoindexter, Brenda B.Sanchez, Pablo J.Shankaran, SeethaStoll, Barbara J.Truog, WilliamVan Meurs, Krisa P.Vohr, BettyWalsh, Michele C.Kirpalani, Haresh2016-03-032016-03-032014-06DeMauro, S. B., D’Agostino, J. A., Bann, C., Bernbaum, J., Gerdes, M., Bell, E. F., … on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2014). Developmental Outcomes of Very Preterm Infants with Tracheostomies. The Journal of Pediatrics, 164(6), 1303–1310.e2. http://doi.org/10.1016/j.jpeds.2013.12.0140022-3476https://hdl.handle.net/1805/8659Objectives To evaluate the neurodevelopmental outcomes of very preterm (<30 weeks) infants who underwent tracheostomy. Study design Retrospective cohort study from 16 centers of the NICHD Neonatal Research Network over 10 years (2001-2011). Infants who survived to at least 36 weeks (N=8,683), including 304 infants with tracheostomies, were studied. Primary outcome was death or neurodevelopmental impairment (NDI, a composite of one or more of: developmental delay, neurologic impairment, profound hearing loss, severe visual impairment) at a corrected age of 18-22 months. Outcomes were compared using multiple logistic regression. We assessed impact of timing, by comparing outcomes of infants who underwent tracheostomy before and after 120 days of life. Results Tracheostomies were associated with all neonatal morbidities examined, and with most adverse neurodevelopmental outcomes. Death or NDI occurred in 83% of infants with tracheostomies and 40% of those without [odds ratio (OR) adjusted for center 7.0 (95%CI, 5.2-9.5)]. After adjustment for potential confounders, odds of death or NDI remained higher [OR 3.3 (95%CI, 2.4-4.6)], but odds of death alone were lower [OR 0.4 (95%CI, 0.3-0.7)], among infants with tracheostomies. Death or NDI was lower in infants who received their tracheostomies before, rather than after, 120 days of life [adjusted OR 0.5 (95%CI, 0.3-0.9)]. Conclusions Tracheostomy in preterm infants is associated with adverse developmental outcomes, and cannot mitigate the significant risk associated with many complications of prematurity. These data may inform counseling about tracheostomy in this vulnerable population.en-USPublisher PolicyCentral Nervous System DiseasesepidemiologyDevelopmental DisabilitiesdiagnosisHospital MortalitytrendsInfant, Extremely PrematureTracheostomyadverse effectsArticle