Manica, MattiaGuzzetta, GiorgioRiccardo, FlaviaValenti, AntonioPoletti, PieroMarziano, ValentinaTrentini, FilippoAndrianou, XanthiUrdiales, Alberto Mateodel Manso, MartinaFabiani, MassimoVescio, Maria FeniciaSpuri, MatteoPetrone, DanieleBella, AntoninoIavicoli, SergioAjelli, MarcoBrusaferro, SilvioPezzotti, PatrizioMerler, Stefano2021-03-262021-03-262021Manica, M., Guzzetta, G., Riccardo, F., Valenti, A., Poletti, P., Marziano, V., ... & Merler, S. (2021). Effectiveness of regional restrictions in reducing SARS-CoV-2 transmission during the second wave of COVID-19, Italy. medRxiv. https://doi.org/10.1101/2021.01.10.21249532https://hdl.handle.net/1805/25474To counter the second COVID-19 wave, the Italian government has adopted a scheme of three sets of restrictions (coded as yellow, orange, and red) imposed on a regional basis. We estimate that milder restrictions in regions at lower risk (yellow) resulted in a transmissibility reduction of about 18%, leading to a reproduction number Rt of about 0.99. Stricter measures (orange and red) led to reductions of 34% and 45% and Rt values of about 0.89 and 0.77 respectively.enAttribution-NonCommercial-NoDerivatives 4.0 InternationalSARS-CoV-2COVID-19ItalyArticle