Lee, BitBasavarajappa, Halesha D.Sulaiman, Rania S.Fei, XiangSeo, Seung-YongCorson, Timothy W.2016-08-232016-08-232014-10-21Lee, B., Basavarajappa, H. D., Sulaiman, R. S., Fei, X., Seo, S.-Y., & Corson, T. W. (2014). First Synthesis of the Antiangiogenic Homoisoflavanone, Cremastranone. Organic & Biomolecular Chemistry, 12(39), 7673–7677. http://doi.org/10.1039/c4ob01604ahttps://hdl.handle.net/1805/10755An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.en-USPublisher PolicyAngiogenesis InhibitorsCell ProliferationHuman Umbilical Vein Endothelial CellsIsoflavonesArticle