Kusmierczyk, Andrew RMartin, Jörg2014-10-072014-10-072001-09Kusmierczyk, A. R., & Martin, J. (2001). Chaperonins–keeping a lid on folding proteins. FEBS letters, 505(3), 343-347.https://hdl.handle.net/1805/5205Two classes of chaperonins are known in all groups of organisms to participate in the folding of newly synthesized proteins. Whereas bacterial type I chaperonins use a reversibly binding cofactor to temporarily sequester folding substrate proteins within the cylindrical chaperonin cavity, type II chaperonins in archaea and the eukaryotic cytosol appear to have evolved a built-in lid for this purpose. Not entirely surprisingly, this has consequences for the folding modes of the two types of chaperonins.en-USprotein foldingchaperoninsgroELArticle