DuBois, Aubrey E.Gregory, Richard L.2016-03-102016-03-102015-04-17Aubrey E. DuBois and Richard L. Gregory. (2015, April 17). Effect of Caffeine on the Growth of Streptococcus mutans. Poster session presented at IUPUI Research Day 2015, Indianapolis, Indiana.https://hdl.handle.net/1805/8803poster abstractCaffeine consumption is a staple of the typical adult diet. Previous research has demonstrated many possible health benefits of regular consumption of caffeine-containing beverages such as coffee and tea. Coffee may contain up 200 mg caffeine/cup (84 μg/ml). This study investigated the correlation between oral health and caffeine consumption by observing the effects of the compound on the growth of a leading contributor to tooth decay, Streptococcus mutans. Assays were performed to examine the effect of different concentrations of caffeine on both the planktonic and biofilm growth of the bacteria. Caffeine concentrations of 200 and 400 μg/ml demonstrated significant biofilm formation enhancement (p<0.05). Contrastingly, concentrations from 31.25 through 100 μg/ml caused a slight, significant inhibition in biofilm formation. Planktonic growth of S. mutans was marginally inhibited in concentrations of 31.25 through 200 μg/ml. The results of this study indicate a potential for adverse side effects to oral health when caffeine is consumed in high concentrations. Lower concentrations such as those naturally found in coffee and tea may inhibit formation of biofilm and dental plaque, thereby promoting good oral health.en-USCaffeine consumptionStreptococcus mutanstooth decayoral healthbacteriaPoster