Landis, Benjamin J.Cooper, David S.Hinton, Robert B.2017-07-312017-07-312016-01Landis, B. J., Cooper, D. S., & Hinton, R. B. (2016). CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes. Cardiology in the Young, 26(1), 30–52. http://doi.org/10.1017/S10479511150013891467-1107https://hdl.handle.net/1805/13675CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes--for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.en-USPublisher PolicyHeart Defects, CongenitalSurgeryHeart DiseasescongenitalArticle