Koller, Daniel L.Imel, Erik A.Lai, DongbingPadgett, Leah R.Acton, DenaGray, AmiePeacock, MunroEcons, Michael J.Foroud, Tatiana2017-07-252017-07-252016-03Koller, D. L., Imel, E. A., Lai, D., Padgett, L. R., Acton, D., Gray, A., … Foroud, T. (2016). Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. Blood Cells, Molecules & Diseases, 57, 50–53. http://doi.org/10.1016/j.bcmd.2015.12.002https://hdl.handle.net/1805/13568A genome-wide association study was performed in 1,130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10−14) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p= 4×10−7), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10−8) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein. No significant associations were detected with serum iron, but variants in HFE were suggestive (p=10−6). Our results corroborate prior studies in older subjects and demonstrate that the association of these genetic variants with iron phenotypes can be detected in premenopausal women.en-USPublisher PolicyIronPremenopausalGWASTransferrinHemochromatosisArticle