Schwarz, Adam J.Shcherbinin, SergeySlieker, Lawrence J.Risacher, Shannon L.Charil, ArnaudIrizarry, Michael C.Fleisher, Adam S.Southekal, SudeeptiJoshi, Abhinay D.Devous, Michael D., Sr.Miller, Bradley B.Saykin, Andrew J.Alzheimer's Disease Neuroimaging Initiative2018-10-112018-10-112018-02-14Schwarz, A. J., Shcherbinin, S., Slieker, L. J., Risacher, S. L., Charil, A., Irizarry, M. C., … Alzheimer’s Disease Neuroimaging Initiative. (2018). Topographic staging of tau positron emission tomography images. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 10, 221–231. http://doi.org/10.1016/j.dadm.2018.01.006https://hdl.handle.net/1805/17501Introduction: It has been proposed that the signal distribution on tau positron emission tomography (PET) images could be used to define pathologic stages similar to those seen in neuropathology. Methods: Three topographic staging schemes for tau PET, two sampling the temporal and occipital subregions only and one sampling cortical gray matter across the major brain lobes, were evaluated on flortaucipir F 18 PET images in a test-retest scenario and from Alzheimer's Disease Neuroimaging Initiative 2. Results: All three schemes estimated stages that were significantly associated with amyloid status and when dichotomized to tau positive or negative were 90% to 94% concordant in the populations identified. However, the schemes with fewer regions and simpler decision rules yielded more robust performance in terms of fewer unclassified scans and increased test-retest reproducibility of assigned stage. Discussion: Tau PET staging schemes could be useful tools to concisely index the regional involvement of tau pathology in living subjects. Simpler schemes may be more robust.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesAV-1451AlzheimerBraakClassificationFlortaucipirImagePETStageStagingT807TauArticle