Glosson-Byers, Nicole L.Sehra, SaritaKaplan, Mark H.2016-10-072016-10-072014-10-30Glosson-Byers, N. L., Sehra, S., & Kaplan, M. H. (2014). STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells. JAK-STAT, 3(3), e955393. http://doi.org/10.4161/21623988.2014.955393https://hdl.handle.net/1805/11138STAT4 is a critical mediator of inflammatory immunity and is required for all known IL-12 biological responses, including the induction of IFN-γ and development of Th1 cells. We demonstrate that IL-23, an IL-12-related cytokine, also requires STAT4 for optimal IL-17 secretion from memory T helper cells and NKT cells. Although IL-23 stimulation had modest effects on STAT4 activation, STAT4-deficiency results in reduced Il23r expression. These data demonstrate a restricted requirement for STAT4 in innate and adaptive IL-17-secreting T cell responses that might contribute to inflammatory immunity.en-USPublisher PolicyIL-23Rmemory ThNKTSTAT4Th17Article