Wong, Li PingLi Ping, HaridahDanaee, MahmoudAhmed, JamilLachyan, AbhishekCai, Carla ZiLin, YulanHu, ZhijianTan, Si YingLu, YixiaoCai, GuoxiNguyen, Di KhanhSeheli, Farhana NishatAlhammadi, FatmaMadhale, Milkar D.Atapattu, MudithaQuazi-Bodhanya, TasmiMohajer, SamiraZimet, Gregory D.Zhao, Qinjian2022-02-182022-02-182021-10Wong, L. P., Li Ping, H., Danaee, M., Ahmed, J., Lachyan, A., Cai, C. Z., Lin, Y., Hu, Z., Tan, S. Y., Lu, Y., Cai, G., Nguyen, D. K., Seheli, F. N., Alhammadi, F., Madhale, M. D., Atapattu, M., Quazi-Bodhanya, T., Mohajer, S., Zimet, G. D., & Zhao, Q. (2021). COVID-19 vaccination intention and vaccine characteristics influencing vaccination acceptance: A global survey of 17 countries. Infectious Diseases of Poverty, 10(1), 122. https://doi.org/10.1186/s40249-021-00900-w2049-9957https://hdl.handle.net/1805/27855BACKGROUND: The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines present a dilemma in vaccination choices, which may result in individuals refusing a particular COVID-19 vaccine offered, hence presenting a threat to immunisation coverage and reaching herd immunity. The study aimed to assess global COVID-19 vaccination intention, vaccine characteristics influencing vaccination acceptance and desirable vaccine characteristics influencing the choice of vaccines. METHODS: An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 countries worldwide. Proportions and the corresponding 95% confidence intervals (CI) of COVID-19 vaccine acceptance and vaccine characteristics influencing vaccination acceptance were generated and compared across countries and regions. Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy. RESULTS: Of the 19,714 responses received, 90.4% (95% CI 81.8-95.3) reported likely or extremely likely to receive COVID-19 vaccine. A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia (96.4%), China (95.3%) and Norway (95.3%), while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan (34.6%), the U.S. (29.4%) and Iran (27.9%). Males, those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy. Less than two-thirds (59.7%; 95% CI 58.4-61.0) reported only being willing to accept a vaccine with an effectiveness of more than 90%, and 74.5% (95% CI 73.4-75.5) said they would accept a COVID-19 vaccine with minor adverse reactions. A total of 21.0% (95% CI 20.0-22.0) reported not accepting an mRNA vaccine and 51.8% (95% CI 50.3-53.1) reported that they would only accept a COVID-19 vaccine from a specific country-of-origin. Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology. The highest proportion from Europe and the Americas would only accept a vaccine produced by certain countries. The foremost important vaccine characteristic influencing vaccine choice is adverse reactions (40.6%; 95% CI 39.3-41.9) of a vaccine and effectiveness threshold (35.1%; 95% CI 33.9-36.4). CONCLUSIONS: The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the importance of designing an efficient plan for the delivery of interventions dynamically tailored to the local population.en-USAttribution 4.0 United StatesSocioeconomic FactorsCOVID-19FemaleSurveys and QuestionnairesCOVID-19 vaccineAdolescentYoung AdultArticle