Sundaram, SunehaVuppalanchi, RajSaxena, RomilChalasani, Naga2020-06-242020-06-242020-02Sundaram, S., Vuppalanchi, R., Saxena, R., & Chalasani, N. (2020). Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids. ACG case reports journal, 7(2), e00319. https://doi.org/10.14309/crj.0000000000000319https://hdl.handle.net/1805/23065Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalDrug-induced liver injuryMorbidityMortalityCorticosteroid therapyControlled patient trialsArticle