Zhang, ChengsenGlaros, TrevorManicke, Nicholas E.2018-03-232018-03-232017-07Zhang, C., Glaros, T., & Manicke, N. E. (2017). Targeted Protein Detection Using an All-in-One Mass Spectrometry Cartridge. Journal of the American Chemical Society, 139(32), 10996–10999. https://doi.org/10.1021/jacs.7b05571https://hdl.handle.net/1805/15688We developed a simple 3D printed cartridge for mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modifications (PTMs). The cartridge uses an integrated antibody enrichment column to preconcentrate the protein target as well as a novel built-in substrate to ionize the protein targets for MS detection. We show several examples of using this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples.enPublisher Policymass spectrometry3D printed cartridgetargeted protein detectionArticle