DiMeglio, Linda A.Evans-Molina, CarmellaOram, Richard A.2019-09-052019-09-052018-06-16DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018). Type 1 diabetes. Lancet (London, England), 391(10138), 2449–2462. doi:10.1016/S0140-6736(18)31320-5https://hdl.handle.net/1805/20795Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.en-USPublisher PolicyBlood GlucoseDiabetes Mellitus, Type 1Glycated Hemoglobin AHaplotypesHypoglycemic AgentsArticle