Zhang, E.Abdel-Mottaleb, M.Liang, P.Navarrete, B.Akin Yildirim, Y.Alberteris Campos, M.Smith, I. T.Wang, P.Yildirim, B.Yang, L.Chen, S.Smith, I.Lur, G.Nguyen, T.Jin, X.Noga, B. R.Ganzer, P.Khizroev, S.2024-06-072024-06-072022Zhang E, Abdel-Mottaleb M, Liang P, et al. Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles [published correction appears in Brain Stimul. 2023 Jul-Aug;16(4):981]. Brain Stimul. 2022;15(6):1451-1462. doi:10.1016/j.brs.2022.10.004https://hdl.handle.net/1805/41287The in vitro study demonstrates wirelessly controlled modulation of neural activity using magnetoelectric nanoparticles (MENPs), synchronized to magnetic field application with a sub-25-msec temporal response. Herein, MENPs are sub-30-nm CoFe2O4@BaTiO3 core-shell nanostructures. MENPs were added to E18 rat hippocampal cell cultures (0.5 μg of MENPs per 100,000 neurons) tagged with fluorescent Ca2+ sensitive indicator cal520. MENPs were shown to wirelessly induce calcium transients which were synchronized with application of 1200-Oe bipolar 25-msec magnetic pulses at a rate of 20 pulses/sec. The observed calcium transients were similar, in shape and magnitude, to those generated through the control electric field stimulation with a 50-μA current, and they were inhibited by the sodium channel blocker tetrodotoxin. The observed MENP-based magnetic excitation of neural activity is in agreement with the non-linear M - H hysteresis loop of the MENPs, wherein the MENPs' coercivity value sets the threshold for the externally applied magnetic field.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalCalciumMagnetic fieldsNanoparticlesNeuronsArticle