He, RongjunBai, YunpengYu, Zhi-HongWu, LiGunawan, Andrea MichelleZhang, Zhong-Yin2016-08-232016-08-232014-10He, R., Bai, Y., Yu, Z.-H., Wu, L., Gunawan, A. M., & Zhang, Z.-Y. (2014). Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis. MedChemComm, 5(10), 1496–1499. http://doi.org/10.1039/C4MD00099Dhttps://hdl.handle.net/1805/10754Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of Tuberculosis (TB). Small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strategy, we successfully developed a salicylic acid based and drug-like mPTPB inhibitor with an IC50 of 2 μM and >20-fold specificity over many human PTPs, making it an excellent lead molecule for anti-TB drug discovery. In addition, DOS generated bicyclic salicylic acids are also promising starting points for acquiring inhibitors targeting other PTPs.en-USPublisher PolicyMycobacterium protein tyrosine phosphatase BTuberculosisTB drug resistanceArticle