Green, Mark A.Eitel, Jacob A.Fletcher, James W.Mathias, Carla J.Tann, Mark A.Gardner, ThomasKoch, Michael O.Territo, WendyPolson, HeatherHutchins, Gary D.2017-10-192017-10-192017-02Green, M. A., Eitel, J. A., Fletcher, J. W., Mathias, C. J., Tann, M. A., Gardner, T., ... & Hutchins, G. D. (2016). Estimation of radiation dosimetry for (68) Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer. Nuclear medicine and biology, 46, 32. https://doi.org/10.1016/j.nucmedbio.2016.11.002https://hdl.handle.net/1805/14344Introduction This study was performed to estimate the human radiation dosimetry for [68Ga]Ga-HBED-CC (PSMA-11) (68Ga PSMA-11). Methods Under an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of 68Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [11C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0–10 min post-injection with the pelvis in the field-of-view. Whole-body images were acquired, pelvis-to-head, at 15, 60, and 90-min post-injection. Additional images of the pelvis were acquired at 40-min and 115-min, and voided urine collected from each subject at 48-min and 120-min post-injection. Radiation dosimetry estimates were calculated from these data using the OLINDA software package. Results Renal uptake was high and relatively invariant, ranging from 11% to 14% of the injected dose between 15 and 90-min post-injection. Radioactivity collected in the voided urine accounted for 14% of the injected dose over a period of 120-min. Lymph nodes and skeletal metastases suspicious for prostate cancer recurrence were detected in a greater number of patients using 68Ga PSMA-11 than using 11C-acetate. Conclusion Kidneys are the critical organ following 68Ga PSMA-11 administration, receiving an estimated dose of 0.413 mGy/MBq. Advances in knowledge and implications for patient care This study confirms that the kidneys will be the critical organ following intravenous administration of 68Ga PSMA-11, and provided data consistent with the expectation that 68Ga PSMA-11 will be superior to [11C]acetate for defining sites of recurrence in prostate cancer patients presenting with biochemical relapse.enPublisher Policy68Ga-HBED-CC (PSMA-11)PSMA-targeted PET/CTprostate cancer recurrenceArticle