Kasting, Monica L.Head, Katharine J.Cox, DenaCox, Anthony D.Zimet, Gregory D.2021-08-082021-08-082019-08-09Kasting, M. L., Head, K. J., Cox, D., Cox, A. D., & Zimet, G. D. (2019). The effects of message framing and healthcare provider recommendation on adult hepatitis B vaccination: A randomized controlled trial. Preventive Medicine, 127, 105798. https://doi.org/10.1016/j.ypmed.2019.1057980091-7435https://hdl.handle.net/1805/26346Many adults in the U.S. do not receive recommended vaccines, and the research literature remains inconclusive on the best communication strategies for increasing this behavior. This study examined the association of message framing (gained-framed vs. loss-framed vs. control), and healthcare provider (HCP) recommendation (offered vs. recommended) on uptake of adult hepatitis B virus (HBV) vaccination in a high risk population using a 3×2 block design randomized controlled trial. Fear of shots, fear of vaccines, and perceived message framing were examined in secondary analyses. Of the 1,747 participants, 47.7% (n=833) received 0 doses of HBV vaccine, 27.8% (n=485) received 1 dose, 10.4% received 2 doses, and 14.1% received all 3 recommended doses. There was not a significant interaction between message framing and HCP recommendation (p =.59). Mean number of doses received by the gain-framed group (m=.96) was not significantly different from the loss-framed group (m=.97, RR=.99, 95% CI=.88–1.12). However, those receiving any framing message received significantly more doses (m= .96) than those in the control condition (m=.81, RR=1.17, 95%CI=1.06–1.31). Participants who received a HCP recommendation received significantly more vaccine doses (m=.95) than those in the vaccine-offered condition (mean=.82, RR=1.16, 95%CI=1.05–1.28). These results suggest there is no difference in vaccine uptake between gain-frame and loss-frame messages, but both are better than a control message. These results also support advising HCP to provide a strong recommendation for vaccinations beyond merely offering it to patients. This study has implications for vaccine uptake beyond HBV, and can inform future research on effective vaccine communication research.en-USProspect Theoryhepatitis b virushepatitis B vaccinesvaccinationvaccine uptakehealth communicationpatient acceptance of healthcarerandomized controlled trialhealth promotionframingArticle