Arroyo, EliottLeber, Cecilia A.Burney, Heather N.Narayanan, GayatriMoorthi, RanjaniAvin, Keith G.Warden , Stuart J.Moe, Sharon M.Lim, Kenneth2024-02-142024-02-142023-11-30Arroyo, E., Leber, C. A., Burney, H. N., Narayanan, G., Moorthi, R., Avin, K. G., Warden, S. J., Moe, S. M., & Lim, K. (2023). Relationship between klotho and physical function in healthy aging. Scientific Reports, 13(21158). https://doi.org/10.1038/s41598-023-47791-5https://hdl.handle.net/1805/38518Epidemiological studies have reported a strong association between circulating Klotho and physical function; however, the cohorts were comprised of older adults with multiple comorbidities. Herein, we examined the relationship between Klotho and physical function in a community-based cohort of healthy adults. In this cross-sectional study, serum Klotho was measured in 80 adults who visited the Musculoskeletal Function, Imaging, and Tissue Resource Core of the Indiana Center for Musculoskeletal Health. Participants (n = 20, 10 [50%] men per group) were chosen into four age groups: 20–34, 35–49, 50–64, and ≥ 65 years, and were further grouped based on performance (low vs. high) on grip strength and chair stand tests. Klotho levels were lower in the ≥ 65 years group (703.0 [189.3] pg/mL; p = 0.022) and the 50–64 years group (722.6 [190.5] pg/mL; p = 0.045) compared to 20–34 years (916.1 [284.8] pg/mL). No differences were observed in Klotho between the low and high performers. The ≥ 65 years group walked a shorter distance during the 6-min walk test (6MWT) compared to 20–34 years (p = 0.005). Klotho was correlated with age (p < 0.001), body fat (p = 0.037), and 6MWT distance (p = 0.022). Klotho levels decline as early as the fifth decade of life, potentially before the onset of age-related impairment in exercise capacity.en-USAttribution 4.0 Internationalcirculating Klothophysical functionage-related impairmentIndiana Center for Musculoskeletal HealthArticle