Korc, PaulMcHenry, Lee2016-12-022016-12-022016-09Korc, P., & McHenry, L. (2016). An uncommon cause of chronic upper GI bleeding. Gastrointestinal Endoscopy, 84(3), 524. https://doi.org/10.1016/j.gie.2016.03.1483https://hdl.handle.net/1805/11530A 68-year-old woman presented with 4 years of iron deficiency anemia, requiring intravenous iron infusion. EGD revealed a 10-mm, cherry-red, sessile polypoid lesion on the major duodenal papilla. EUS examination was negative for deep invasion. Endoscopic ampullectomy was performed. A residual focus of lesion was treated with argon plasma coagulation (APC) after placement of a protective pancreatic duct stent (Video 1, available online at www.giejournal.org). Pathologic examination revealed a proliferation of capillaries with acute and chronic inflammation, consistent with pyogenic granuloma. Figure 1 demonstrates the lesion’s appearance (Fig. 1A) and the histology at ×100 magnification (Fig. 1B). Pyogenic granuloma is a lobular capillary hemangioma that presents as a polypoid red mass. Most often, they occur on the skin or oral mucosa but can, rarely, be found in the GI tract. Pyogenic granuloma of the duodenum is particularly rare. To our knowledge, only 2 cases of pyogenic granuloma (capillary hemangioma) with major papilla involvement have been reported, both in the Spanish language literature (de Caralt, 1986; Camacho, 2012). Pyogenic granuloma should be considered in the differential diagnosis of chronic GI bleeding. If the major papilla is involved, ampullectomy followed by APC for any residual lesion appears to be a safe and effective treatment.enPublisher Policyupper GI bleedingpyogenic granulomaArticle