Han, Sang-WonPark, Young HoBice, Paula J.Bennett, David A.Kim, SangYunSaykin, Andrew J.Nho, Kwangsik2024-11-112024-11-112024Han SW, Park YH, Bice PJ, et al. miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease. Ann Clin Transl Neurol. 2024;11(10):2799-2804. doi:10.1002/acn3.52175https://hdl.handle.net/1805/44448A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi-omics data (N = 702). Among 44 candidate miRNAs, miR-133b was significantly associated with AD and Braak positivity. Higher miR-133b expression was also associated with higher NPTX2 gene expression and better cognition. Mediation analysis showed that miR-133b partially influences AD and cognition through the NPTX2 protein. Our integrated approach suggests a potential role of miR-133b in synaptic integrity and offers new insights into AD pathogenesis.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalAlzheimer diseaseMicroRNAsC-reactive proteinNerve tissue proteinsSynapsesArticle