Chan, Eric K.Brown, CameronBachar, RoudiSmith, AntonioSrivangipuram, Sudarsana2023-10-232023-10-232022-12-05Chan EK, Brown C, Bachar R, Smith A, Srivangipuram S. Takotsubo Cardiomyopathy in the Setting of Myxedema Coma. Cureus. 2022;14(12):e32229. Published 2022 Dec 5. doi:10.7759/cureus.32229https://hdl.handle.net/1805/36548Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyroid hormone replacement in the setting of severe hypothyroidism. Furthermore, TCM can be difficult to anticipate when presenting as a complication of another diagnosis. In this case report, we aim to improve awareness of TCM as a consequence of extreme hypothyroid states.en-USAttribution 4.0 InternationalMyxedema comaTakotsubo cardiomyopathyThyroid hormone replacementArticle