Halverson, Colin M. E.Bland, Sarah T.Leppig, Kathleen A.Marasa, MaddalenaMyers, MelanieRasouly, Hila MiloWynn, JuliaClayton, Ellen Wright2021-08-092021-08-092020-06-18Halverson, C. M. E., Bland, S. T., Leppig, K. A., Marasa, M., Myers, M., Rasouly, H. M., Wynn, J., & Clayton, E. W. (2020). Ethical conflicts in translational genetic research: Lessons learned from the eMERGE-III experience. Genetics in Medicine, 22(10), 1667–1672. https://doi.org/10.1038/s41436-020-0863-91530-0366https://hdl.handle.net/1805/26381Purpose The Electronic Medical Records and Genomics (eMERGE) Consortium integrated biorepository-based research with electronic health records (EHR) to return results from large-scale genetic tests to participants and uploaded those data into the EHR. This article explores the ethical issues investigators encountered in that process. Methods We conducted in-depth, semistructured interviews with study personnel of the eMERGE-III Consortium sites that returned results. Results We discuss major ethical issues that arose while attempting to return research results from the eMERGE Consortium to individual participants. These included difficulties recontacting those participants who had not explicitly consented to such and disclosing results to many participants with insufficient infrastructure and staff. Investigators reported being driven by a supererogatory clinical impulse. Conclusion All these issues ultimately derive from ethical conflicts inherent to translational work being done at the interface of research and clinical care. A critical rethinking of this divide is important, but infrastructural support for such work is necessary for an ethically sound rollout of large-scale genetic testing.en-USAttribution-NonCommercial-NoDerivatives 4.0 Internationalgenomic testingtranslational researchregulationresearch ethicselectronic health recordsArticle