Mukherjee, ShubhabrataKim, SungeunRamanan, Vijay K.Gibbons, Laura E.Nho, KwangsikGlymour, M. MariaErtekin-Taner, NilüferMontine, Thomas J.Saykin, Andrew J.Crane, Paul K.Alzheimer’s Disease Neuroimaging Initiative2015-12-032015-12-032014-03Mukherjee, S., Kim, S., Ramanan, V. K., Gibbons, L. E., Nho, K., Glymour, M. M., … Crane, P. K. (2014). Gene-based GWAS and -biological pathway analysis of the resilience of executive functioning. Brain Imaging and Behavior, 8(1), 110–118. http://doi.org/10.1007/s11682-013-9259-7https://hdl.handle.net/1805/7614Resilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previously reported single nucleotide polymorphism (SNP) genome-wide association study (GWAS) results for EF resilience. Here, we report gene- and pathway-based analyses of the same resilience phenotype, using an optimal SNP-set (Sequence) Kernel Association Test (SKAT) for gene-based analyses (conservative threshold for genome-wide significance = 0.05/18,123=2.8×10−6) and the gene-set enrichment package GSA-SNP for biological pathway analyses (False discovery rate (FDR) < 0.05). Gene-based analyses found a genome-wide significant association between RNASE13 and EF resilience (p=1.33×10−7). Genetic pathways involved with dendritic/neuron spine, presynaptic membrane, postsynaptic density etc. were enriched with association to EF resilience. Although replication of these results is necessary, our findings indicate the potential value of gene- and pathway-based analyses in research on determinants of cognitive resilience.en-USPublisher PolicyMemoryexecutive functioningAlzheimer’s diseasegenesresiliencepathwaysArticle