Tizabi, YousefGetachew, BrukHauser, Sheketha R.Tsytsarev, VassiliyManhães, Alex C.da Silva, Victor Diogenes Amaral2024-08-232024-08-232024-05-30Tizabi Y, Getachew B, Hauser SR, Tsytsarev V, Manhães AC, da Silva VDA. Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction. Brain Sci. 2024;14(6):558. Published 2024 May 30. doi:10.3390/brainsci14060558https://hdl.handle.net/1805/42913Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.en-USAttribution 4.0 InternationalAstrocytesGlial cellsGut microbiotaMajor depressive disorderMicrogliaNeuroinflammationNeurotrophic factorsOligodendrocytesSubstance use disorderSynantocytesArticle