Mei, LiyeShen, HuiYu, YalanWeng, YueyunLi, XiaoxiaoZahid, Kashif RafiqHuang, JinWang, DuLiu, ShengZhou, FulingLei, Cheng2023-10-022023-10-022022-11-23Mei L, Shen H, Yu Y, et al. High-throughput and high-accuracy diagnosis of multiple myeloma with multi-object detection. Biomed Opt Express. 2022;13(12):6631-6644. Published 2022 Nov 23. doi:10.1364/BOE.475166https://hdl.handle.net/1805/35925Multiple myeloma (MM) is a type of blood cancer where plasma cells abnormally multiply and crowd out regular blood cells in the bones. Automated analysis of bone marrow smear examination is considered promising to improve the performance and reduce the labor cost in MM diagnosis. To address the drawbacks in established methods, which mainly aim at identifying monoclonal plasma cells (monoclonal PCs) via binary classification, in this work, considering that monoclonal PCs is not the only basis in MM diagnosis, for the first we construct a multi-object detection model for MM diagnosis. The experimental results show that our model can handle the images at a throughput of 80 slides/s and identify six lineages of bone marrow cells with an average accuracy of 90.8%. This work makes a step further toward full-automatic and high-efficiency MM diagnosis.en-USAttribution 4.0 InternationalMultiple myelomaBlood cancerBone marrowMonoclonal plasma cellsArticle