Layton, JillLi, XiaochenShen, Changyude Groot, MaryLange, LeslieCorrea, AdolfoWessel, Jennifer2018-06-062018-06-062018-01-03Layton, J., Li, X., Shen, C., de Groot, M., Lange, L., Correa, A., & Wessel, J. (2018). Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status. Clinical Medicine Insights. Endocrinology and Diabetes, 11, 1179551417748942. http://doi.org/10.1177/1179551417748942https://hdl.handle.net/1805/16364The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.Attribution-NonCommercial 3.0 United StatesAfrican American healthType 2 diabetesGenetic epidemiologyGenetic risk factorsRisk predictionArticle