Wang, DeshengGomes, Marta T.Mo, YanfeiProhaska, Clare C.Zhang, LuChelvanambi, SarveshClauss, Matthias A.Zhang, DongfangMachado, Roberto F.Gao, MingqiBai, Yang2023-12-152023-12-152023-04-18Wang D, Gomes MT, Mo Y, et al. Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation. Int J Mol Sci. 2023;24(8):7472. Published 2023 Apr 18. doi:10.3390/ijms24087472https://hdl.handle.net/1805/37356Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.en-USAttribution 4.0 InternationalHuman endogenous retrovirus KPulmonary arterial hypertensionHuman immunodeficiency virusSARS-CoV-2InflammationArticle