Slot, Rosalinde E. R.Sikkes, Sietske A. M.Berkhof, JohannesBrodaty, HenryBuckley, RachelCavedo, EnricaDardiotis, EfthimiosGuillo-Benarous, FrancoiseHampel, HaraldKochan, Nicole A.Lista, SimoneLuck, TobiasMaruff, PaulMolinuevo, José LuisKornhuber, JohannesReisberg, BarryRiedel-Heller, Steffi G.Risacher, Shannon L.Roehr, SusanneSachdev, Perminder S.Scarmeas, NikolaosScheltens, PhilipShulman, Melanie B.Saykin, Andrew J.Verfaillie, Sander C. J.Visser, Pieter JelleVos, Stephanie J. B.Wagner, MichaelWolfsgruber, SteffenJessen, Frank2019-08-022019-08-022019-03Slot, R., Sikkes, S., Berkhof, J., Brodaty, H., Buckley, R., Cavedo, E., … van der Flier, W. M. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 15(3), 465–476. doi:10.1016/j.jalz.2018.10.003https://hdl.handle.net/1805/20150INTRODUCTION: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. METHODS: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. RESULTS: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. DISCUSSION: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.en-USPublisher PolicyAlzheimer's diseaseDementia Lewy bodiesDementia incidenceFrontotemporal dementiaPreclinical Alzheimer's diseaseSubjective cognitive declineVascular dementiaArticle