Ng, YenLacy, Jeffrey L.Fletcher, James W.Green, Mark A.2016-02-292016-02-292014-09Ng, Y., Lacy, J. L., Fletcher, J. W., & Green, M. A. (2014). Performance of a 62Zn/62Cu Microgenerator in Kit-Based Synthesis and Delivery of [62Cu]Cu-ETS for PET Perfusion Imaging. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine, 91, 38–43. http://doi.org/10.1016/j.apradiso.2014.05.006https://hdl.handle.net/1805/8594The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84 ± 0.23 GBq 62Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672 ± 172 MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for “on-demand” delivery of [62Cu]Cu-ETS for PET perfusion imaging.en-USPublisher Policy62Zn/62Cu generatorPET radiopharmaceuticals[62Cu]Cu-ETS (copper(II) ethylglyoxal bis(thiosemicarbazone))tumor perfusionArticle