Zhang, MinMandraju, RajakumarRai, UrvashiShiratsuchi, TakayukiTsuji, Moriya2020-01-022020-01-022017-08-23Zhang, M., Mandraju, R., Rai, U., Shiratsuchi, T., & Tsuji, M. (2017). Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies (Basel, Switzerland), 6(3), 11. doi:10.3390/antib6030011https://hdl.handle.net/1805/21680Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3-specific for the central repeat region-have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s.en-USPlasmodium falciparumCircumsporozoite proteinCSPMonoclonal antibody2A103C13C23D3Article