Gohil, AnishaMalin, StefanAbulebda, KamalHannon, Tamara S.2022-09-282022-09-282021Gohil A, Malin S, Abulebda K, Hannon TS. A Complicated Case of COVID-19 and Hyperglycemic Hyperosmolar Syndrome in an Adolescent Male. Horm Res Paediatr. 2021;94(1-2):71-75. doi:10.1159/000514281https://hdl.handle.net/1805/30148This article is made available for unrestricted research re-use and secondary analysis in any form or be any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Emerging data demonstrate that comorbid conditions and older age are contributing factors to COVID-19 severity in children. Studies involving youth with COVID-19 and diabetes are lacking. We report the case of a critically ill adolescent male with obesity, type 2 diabetes, and COVID-19 who presented with hyperglycemic hyperosmolar syndrome (HHS). This case highlights a challenge for clinicians in distinguishing severe complications of COVID-19 from those seen in HHS. Youth with obesity and type 2 diabetes may represent a high-risk group for severe COVID-19 disease, an entity that to date has been well-recognized in adults but remains rare in children and adolescents.en-USPublic Health EmergencyHyperglycemic hyperosmolar stateDiabetic ketoacidosisCoronavirus disease 2019 infectionType 2 diabetesArticle