Nurnberger, John I., Jr.Foroud, TatianaFlury, LeahMeyer, Eric T.Wiegand, Ryan2019-10-232019-10-232002Nurnberger, J. I., Jr, Foroud, T., Flury, L., Meyer, E. T., & Wiegand, R. (2002). Is there a genetic relationship between alcoholism and depression?. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 26(3), 233–240.https://hdl.handle.net/1805/21241The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression. Among alcoholic subjects the COGA study found an increased prevalence of depressive syndrome (i.e., depression that may or may not occur in conjunction with increased drinking). This combination of alcoholism and depression tends to run in families. Comorbid alcoholism and depression occurred substantially more often in first-degree relatives of COGA participants with alcoholism than in relatives of control participants. Based on these data, COGA investigators defined three phenotypes—“alcoholism,” “alcoholism and depression,” and “alcoholism or depression”—and analyzed whether these phenotypes were linked to specific chromosomal regions. These analyses found that the “alcoholism or depression” phenotype showed significant evidence for genetic linkage to an area on chromosome 1. This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced).en-USPublisher PolicyGenetic theory of AODU (alcohol and other drug use)AOD dependenceGenetic traitMajor depressionMood and affect disturbanceComorbidityPhenotypeChromosomeAODR (alcohol and other drug related) genetic markersPrevalenceGender differencesGenetic linkageArticle