Hajj, Ihab I.Wu, HowardReuss, SarahRandolph, MelissaHarris, AkeemGromski, MarkAl-Haddad, Mohammad2019-06-072019-06-072018-11El Hajj, I. I., Wu, H., Reuss, S., Randolph, M., Harris, A., Gromski, M. A., & Al-Haddad, M. (2018). Prospective Assessment of the Performance of a New Fine Needle Biopsy Device for EUS-Guided Sampling of Solid Lesions. Clinical endoscopy, 51(6), 576–583. doi:10.5946/ce.2018.053https://hdl.handle.net/1805/19563BACKGROUND/AIMS: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) remains the most common EUS-guided tissue acquisition technique. This study aimed to evaluate the performance of a new Franseen tip fine needle biopsy (FNB) device for EUSguided sampling of solid lesions and compare it with the historical FNA technique. METHODS: Acquire® 22 G FNB needle (Boston Scientific Co., Natick, MA, USA) was used for solid tumor sampling (Study group). Tissue was collected for rapid on-site evaluation, and touch and crush preparations were made. Historical EUS-FNA samples obtained using Expect® 22 G FNA needle (Boston Scientific Co.) were used as controls (Control group). All specimens were independently evaluated by two cytopathologists blinded to the formal cytopathological diagnosis. RESULTS: Mean cell block histology scores were significantly higher (p=0.046) in the FNB group (51 samples) despite a significantly lower (p<0.001) mean number of passes compared to the FNA group (50 specimens). The overall diagnostic yields for the FNB vs. FNA groups were 96% vs. 88%. The degree of tumor differentiation was adequately assessed in all cell block qualifying lesions in the FNB group. Two patients developed post-FNB abdominal pain. CONCLUSION: The new Franseen tip FNB device provides histologically superior and cytologically comparable specimens to those obtained by FNA, but with fewer passes.Attribution-NonCommercial-NoDerivs 3.0 United StatesEndoscopic ultrasound-guided fine needle aspirationEndoscopic ultrasound-guided fine needle biopsyTissue acquisitionArticle