Abedali, Zain A.Large, TimHeiman, Joshua M.Bandali, ElhaamAnderson, Blake B.Lingeman, James E.Krambeck, Amy E.2020-10-232020-10-232019Abedali, Z. A., Large, T., Heiman, J. M., Bandali, E., Anderson, B. B., Lingeman, J. E., & Krambeck, A. E. (2019). Percutaneous Nephrolithotomy in the 80 Years of Age and Older Population. Urology, 134, 62–65. https://doi.org/10.1016/j.urology.2019.08.044https://hdl.handle.net/1805/24174Objective To evaluate feasibility of percutaneous nephrolithotomy (PCNL) for complex nephrolithiasis in patients 80 years of age and older compared to younger individuals. Methods From an institutional IRB-approved database, 1,647 patients were identified who underwent PCNL from 1999 to 2019. Patients were stratified by age: group 1 (20-59), group 2 (60-79), and group 3 (>80). Statistics were performed using chi-square and ANOVA to compare outcomes. Results Of the 1,647 patients, median age was 46, 66, and 83, respectively ( P <0.0001). Three patients within group 3 were 90 or older. Females made up 54%, 46%, 56% of patients ( P = 0.02). Average stone size with SD was 2.6 ± 2.2, 2.5 ± 2.3, 2.2± 1.9 cm for each group ( P = 0.06). Mean preoperative hemoglobin (Hgb) was significantly lower in the 80+ group (13.8, 13.4, 13.1 g/dL, P <.0001). Change in Hgb was not significantly different. There were more Clavien II-IV complications (10.4, 14.4, 28.8%; P = 0.02) and transfusions (2.3, 4.7, 10.2%; P <0.001) in the elderly. The most common complications in the 80+ group were bleeding related (10.1%). No difference in readmission rates or ICU admissions was noted. Conclusion PCNL is feasible in the extremely elderly; however with a higher rate of complications and longer hospitalizations. No long-term sequelae or deaths in the 80 and older cohort were seen. This study allows us to appropriately counsel older patients on a realistic postoperative course and supports use of PCNL as the best means of long-term survival.enPublisher Policypercutaneous nephrolithotomypatient agePCNLArticle