Lee, Daniel D.Schwarz, Margaret A.2022-08-242022-08-242020-04Lee DD, Schwarz MA. Cell-Cell Communication Breakdown and Endothelial Dysfunction. Crit Care Clin. 2020;36(2):189-200. doi:10.1016/j.ccc.2019.11.001https://hdl.handle.net/1805/29859Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.en-USPublisher PolicyDevelopmentDiseaseDysfunctionEndotheliumHeterogeneitySignalingArticle