Mayhew, Jonathan A.Christenson, John C.Alali, Muayad2024-06-242024-06-242024Mayhew JA, Christenson JC, Alali M. Recurrent Serratia marcescens osteomyelitis eight years after a contaminated open fracture: a case report and review of the literature. Transl Pediatr. 2024;13(2):350-358. doi:10.21037/tp-23-492https://hdl.handle.net/1805/41799Background: Serratia marcescens (S. marcescens) is an unusual cause of osteomyelitis. Infection may develop following open trauma, intravenous drug abuse, or in the presence of hardware, but osteoarticular infections outside of this context are atypical in the absence of immunodeficiency. Rarely, a chronic indolent infection may develop after open trauma with disease recurrence years after the initial injury. Case description: We present the case of a 16-year-old male with extensive left lower extremity osteomyelitis secondary to S. marcescens eight years after an open fracture to this leg was complicated by an infection with the same organism. Suboptimal therapy of his initial infection may have contributed to persistent, latent disease before recurrence years later. Evaluation for immunodeficiency was negative and he responded well to ciprofloxacin antibiotic therapy. Conclusions: S. marcescens infection may complicate open fractures, and, if not adequately treated, a chronic, indolent infection may result, with disease recurrence years later. We stress the importance of adequate therapy for infectious complications following open fractures and discuss virulence factors of S. marcescens that may allow this organism to evade the immune system and survive subclinically within a host. The optimal therapy of S. marcescens osteomyelitis is not established and further studies are needed to best guide the therapeutic approach.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalSerratia marcescens (S. marcescens)OsteomyelitisOpen fractureChronic granulomatous diseaseCase reportArticle