Butler, Merlin G.Walzak, Myron P.Sanger, Warren G.Todd, Curtis T.2018-01-082018-01-081983-07Butler, M. G., Walzak, M. P., Sanger, W. G., & Todd, C. T. (1983). A Possible Etiology Of The Infertile 46XX Male Subject. The Journal of Urology, 130(1), 154–156.https://hdl.handle.net/1805/14959We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurements of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of XX male subjects are discussed.en-USPublisher PolicySex chromosome abnormalitiesKaryotypesX chromosomeArticle