Chiang, Karldi Scalea, Teresa LanzaSmith, TawnySpelber, DavidSiegel-Ramsay, JenniferNemeroff, Charles B.Strakowski, Stephen M.Almeida, Jorge2025-03-262025-03-262024Chiang K, di Scalea TL, Smith T, et al. The effect of resilience on bipolar mood during specialty clinic treatment. J Affect Disord. 2024;347:314-319. doi:10.1016/j.jad.2023.11.019https://hdl.handle.net/1805/46596Background: Limitations in mental health resources behoove exploration of factors that may enhance treatment response. One such factor, resilience, has been minimally examined in bipolar disorder. Methods: With multi-level modeling of clinical care data, we examined associations among longitudinal measurements of resilience and mood rating trajectories in a sample of 100 individuals with bipolar disorder during 6 weeks of evidence-based pharmacotherapy and psychotherapy. Results: Individuals with high self-care subscale scores from the Resilience Questionnaire for Bipolar Disorder exhibited an improving rate of depression change -0.18 (SE = 0.04, p < .001) completing treatment with a subthreshold depression rating of 3.1 (SE = 1.39, p < .05). In contrast, treatment recipients who disagreed or were neutral towards self-care experienced worsening or no change in depression, respectively. This subscale also decreased mood elevation. Each one-point increase yielded a -0.27 (SE = 0.13 p < .05) point decrease in mania. Limitations: Resilience may develop longitudinally. In this study, it was examined during active treatment which was a relatively brief period of time. Conclusions: Higher bipolar resilience could identify individuals more likely to exhibit improvement in mood during bipolar specialty clinic treatment.en-USPublisher PolicyBipolar disorderEvidence based practicePsychological resiliencePsychotherapyArticle