Hone-Blanchet, AntoineBohsali, AnastasiaKrishnamurthy, Lisa C.Shahid, SalmanLin, QixiangZhao, LipingLoring, DavidGoldstein, FeliciaJohn, Samantha E.Fleischer, Candace C.Levey, AllanLah, JamesQiu, DeqiangCrosson, Bruce2023-10-062023-10-062022Hone-Blanchet A, Bohsali A, Krishnamurthy LC, et al. Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults. Neurobiol Aging. 2022;109:22-30. doi:10.1016/j.neurobiolaging.2021.09.016https://hdl.handle.net/1805/36190Elevated expression of β-amyloid (Aβ1-42) and tau are considered risk-factors for Alzheimer's disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer's disease.en-USPublisher PolicyAgingMagnetic resonance spectroscopyAlzheimer’s diseaseFrontal cortexCerebrospinal fluid biomarkersGeneral cognitionArticle