McGuire, Sean P.Montero, Anne MaryMcGreevy, Kathleen A.Zyromski, Nicholas J.2023-08-022023-08-022022-07-02McGuire SP, Montero AM, McGreevy KA, Zyromski NJ. Pancreatitis associated anxiety, depression, and stress: Hypothesis, definition, and intervention. Surg Open Sci. 2022;10:50-52. Published 2022 Jul 2. doi:10.1016/j.sopen.2022.06.005https://hdl.handle.net/1805/34696Necrotizing pancreatitis is characterized by a prolonged disease course requiring frequent hospitalization and intervention. Necrotizing pancreatitis patients have high rates of intensive care unit admission and organ failure. Critical illness is an identified risk factor for the development of anxiety, depression, and posttraumatic stress disorder. Limited literature examines quality of life in necrotizing pancreatitis patients, and studies examining psychiatric sequalae of necrotizing pancreatitis including depression, anxiety, and posttraumatic stress disorder are virtually nonexistent. Here, we review critical literature examining risk factors for poor mental health outcomes during and after necrotizing pancreatitis, identify several screening instruments to quantify mental health outcomes, and propose an intervention to improve mental health outcomes in patients with necrotizing pancreatitis. We conclude that establishing the incidence of mental health disorders and implementing strategies to improve mental health outcomes are critical to holistic care of necrotizing pancreatitis patients.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalNecrotizing pancreatitisIntensive care unitsOrgan failureCritical illnessAnxietyDepressionPosttraumatic stress disorderArticle