Hornbrook, Mark C.Wendel, Christopher S.Coons, Stephen JoelGrant, MarciaHerrinton, Lisa J.Mohler, M. JaneBaldwin, Carol M.McMullen, Carmit K.Green, Sylvan B.Alschuler, AndreaRawl, Susan M.Krouse, Robert S.2014-04-022014-04-022011-03Hornbrook, M. C., Wendel, C. S., Coons, S. J., Grant, M., Herrinton, L. J., Mohler, M. J., ... & Krouse, R. S. (2011). Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores. Medical care, 49(3), 321.https://hdl.handle.net/1805/4216Background Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multi-dimensional health states across diseases and treatments for research and policy. Objective To assess the effects of living with a permanent intestinal stoma, compared to a major bowel resection, among colorectal cancer (CRC) survivors. Research Design Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects Six-hundred-forty CRC survivors (≥5 years) from three group-model HMOs; ostomates and non-ostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures SF-6D scoring system applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy (mCOH-QOL-O); Charlson-Deyo comorbidity index. Methods Survey of CRC survivors linked to respondents’ clinical data extracted from HMO files. Results Response rate was 52%. Ostomates and non-ostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared to 0.73 for non-ostomates (p <.001), but other factors explained this difference. Complications of initial cancer surgery, and prior-year comorbidity burden and hospital use were negatively associated with SF-6D scores, while household income was positively associated. Conclusions CRC survivors’ SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.en-UScolorectal cancersurvivorshipHRQOLArticle