Lourens, SpencerSunjaya, Dharma B.Singal, AshwaniLiangpunsakul, SuthatPuri, PuneetSanyal, ArunRen, XiaoweiGores, Gregory J.Radaeva, SvetlanaChalasani, NagaCrabb, David W.Katz, BarryKamath, Patrick S.Shah, Vijay H.2019-04-302019-04-302017-04-28Lourens, S., Sunjaya, D. B., Singal, A., Liangpunsakul, S., Puri, P., Sanyal, A., … TREAT Consortium (2017). Acute Alcoholic Hepatitis: Natural History and Predictors of Mortality Using a Multicenter Prospective Study. Mayo Clinic proceedings. Innovations, quality & outcomes, 1(1), 37–48. doi:10.1016/j.mayocpiqo.2017.04.004https://hdl.handle.net/1805/19019Objective: To examine the natural history of acute alcoholic hepatitis (AH) and identify predictors of mortality for AH using data from a prospective multicenter observational study. Participants and Methods: We analyzed data from 164 patients with AH and 131 heavy-drinking controls with no liver disease. Participants underwent clinical/laboratory assessment at baseline and 6 and 12 months after enrollment. Multivariable analyses were conducted to identify variables associated with mortality and examine the association between coffee drinking and risk of AH. Results: Thirty-six patients with AH died during follow-up, with estimated 30-day, 90-day, 180-day, and 1-year survival of 0.91 (95% CI, 0.87-0.96), 0.85 (95% CI, 0.80-0.91), 0.80 (95% CI, 0.74-0.87), and 0.75 (95% CI, 0.68-0.83), respectively. In the multivariable analysis, higher serum bilirubin level (hazard ratio [HR]=1.059; 95% CI, 1.022-1.089), lower hemoglobin level (HR=1.263; 95% CI, 1.012-1.575), and lower platelet count (HR=1.006; 95% CI, 1.001-1.012) were independently associated with mortality in AH. Compared with controls, fewer patients with AH regularly consumed coffee (20% vs 44%; P<.001), and this association between regular coffee drinking and lower risk of AH persisted after controlling for relevant covariates (odds ratio=0.26; 95% CI, 0.15-0.46). Time-dependent receiver operating characteristic curve analysis revealed that Model for End-Stage Liver Disease; Maddrey Discriminant Function; age, serum bilirubin, international normalized ratio, and serum creatinine; and Child-Pugh scores all provided similar discrimination performance at 30 days (area under the curve=0.73-0.77). Conclusion: Alcoholic hepatitis remains highly fatal, with 1-year mortality of 25%. Regular coffee consumption was associated with lower risk of AH in heavy drinkers.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesABICSerum bilirubinAkaike Information CriterionModel for End-Stage Liver DiseaseTranslational Research and Evolving Alcoholic Hepatitis TreatmentArticle