Berger, P.K.Pollock, N.K.Laing, E.M.Warden, S.J.Gallant, K.M. HillHausman, D.B.Tripp, R.A.McCabe, L.D.McCabe, G.P.Weaver, C.M.Peacock, M.Lewis, R.D.2016-06-142016-06-142014-09Berger, P. K., Pollock, N. K., Laing, E. M., Warden, S. J., Hill Gallant, K. M., Hausman, D. B., … Lewis, R. D. (2014). Association of Adenovirus 36 Infection With Adiposity and Inflammatory-Related Markers in Children. The Journal of Clinical Endocrinology and Metabolism, 99(9), 3240–3246. http://doi.org/10.1210/jc.2014-1780https://hdl.handle.net/1805/9937CONTEXT: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. OBJECTIVE: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black). DESIGN: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α, IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry. RESULTS: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P = .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2-4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0-3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05). CONCLUSIONS: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.en-USPublisher PolicyAdenoviridaeAdenovirus Infections, HumanAdiposityAntibodies, ViralInflammationSeroepidemiologic StudiesArticle