Edwards, Paul C.Mason, James M.2013-10-022013-10-022006-05-15Edwards PC, Mason JM. (2006) Gene-enhanced tissue engineering for dental hard tissue regeneration: (I) dentin-pulp and periodontal regeneration. Head Face Med. May 25;2:16.https://hdl.handle.net/1805/3598Gene-based therapies for tissue regeneration involve delivering a specific gene to a target tissue with the goal of changing the phenotype or protein expression profile of the recipient cell; the ultimate goal being to form specific tissues required for regeneration. One of the principal advantages of this approach is that it provides for a sustained delivery of physiologic levels of the growth factor of interest. This manuscript will review the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. Part 2 will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration.en-UStissue engineeringtissue regenerationgene-based therapyArticle