Tirkes, TemelYadav, DhirajConwell, Darwin L.Territo, Paul R.Zhao, XuandongPersohn, Scott A.Dasyam, Anil K.Shah, Zarine K.Venkatesh, Sudhakar K.Takahashi, NaokiWachsman, AshleyLi, LiangLi, YanPandol, Stephen J.Park, Walter G.Vege, Santhi S.Hart, Phil A.Topazian, MarkAndersen, Dana K.Fogel, Evan L.Consortium for the Study of Chronic Pancreatitis, Diabetes, Pancreatic Cancer (CPDPC)2023-08-032023-08-032022Tirkes T, Yadav D, Conwell DL, et al. Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP). Abdom Radiol (NY). 2022;47(11):3792-3805. doi:10.1007/s00261-022-03654-7https://hdl.handle.net/1805/34706Purpose: To determine if quantitative MRI techniques can be helpful to evaluate chronic pancreatitis (CP) in a setting of multi-institutional study. Methods: This study included a subgroup of participants (n = 101) enrolled in the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) study (NCT03099850) from February 2019 to May 2021. MRI was performed on 1.5 T using Siemens and GE scanners at seven clinical centers across the USA. Quantitative MRI parameters of the pancreas included T1 relaxation time, extracellular volume (ECV) fraction, apparent diffusion coefficient (ADC), and fat signal fraction. We report the diagnostic performance and mean values within the control (n = 50) and CP (n = 51) groups. The T1, ECV and fat signal fraction were combined to generate the quantitative MRI score (Q-MRI). Results: There was significantly higher T1 relaxation time; mean 669 ms (± 171) vs. 593 ms (± 82) (p = 0.006), ECV fraction; 40.2% (± 14.7) vs. 30.3% (± 11.9) (p < 0.001), and pancreatic fat signal fraction; 12.2% (± 5.5) vs. 8.2% (± 4.4) (p < 0.001) in the CP group compared to controls. The ADC was similar between groups (p = 0.45). The AUCs for the T1, ECV, and pancreatic fat signal fraction were 0.62, 0.72, and 0.73, respectively. The composite Q-MRI score improved the diagnostic performance (cross-validated AUC: 0.76). Conclusion: Quantitative MR parameters evaluating the pancreatic parenchyma (T1, ECV fraction, and fat signal fraction) are helpful in the diagnosis of CP. A Q-MRI score that combines these three MR parameters improves diagnostic performance. Further studies are warranted with larger study populations including patients with acute and recurrent acute pancreatitis and longitudinal follow-ups.en-USPublisher PolicyChronic pancreatitisExtracellular volume fractionFat signal fractionT1 mappingArticle