Jones, Josette F.Webster, Yue WangPalakal, Mathew J.Schadow, GuntherDow, Ernst R.2010-06-012010-06-012010-06-01https://hdl.handle.net/1805/2145http://dx.doi.org/10.7912/C2/906Indiana University-Purdue University Indianapolis (IUPUI)Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with different interests. We designed and implemented a hybrid knowledge discovery framework. We developed strategies to leverage both traditional biomedical databases and Health Social Network Communities content in the discovery process. Heuristic and quantitative evaluations were carried out in Colorectal Cancer and Amyotrophic Lateral Sclerosis disease areas. The results demonstrate the potential of our approach to bridge silos and to identify hidden links among clinical observations, drugs, genes and diseases, which may eventually lead to the discovery of novel disease targets, biomarkers and therapies.en-USTranslational ResearchInformation storage and retrieval systems -- MedicineMedical informatics