Aloi, JosephCrum, Kathleen I.Blair, Karina S.Zhang, RuBashford-Largo, JohannahBajaj, SahilSchwartz, AmandaCarollo, ErinHwang, SoonjoLeiker, EmilyFilbey, Francesca M.Averbeck, Bruno B.Dobbertin, MatthewBlair, R. James R.2022-08-042022-08-042021-04Aloi J, Crum KI, Blair KS, et al. Individual associations of adolescent alcohol use disorder versus cannabis use disorder symptoms in neural prediction error signaling and the response to novelty. Dev Cogn Neurosci. 2021;48:100944. doi:10.1016/j.dcn.2021.100944https://hdl.handle.net/1805/29720Two of the most commonly used illegal substances by adolescents are alcohol and cannabis. Alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with poorer decision-making in adolescents. In adolescents, level of AUD symptomatology has been negatively associated with striatal reward responsivity. However, little work has explored the relationship with striatal reward prediction error (RPE) representation and the extent to which any augmentation of RPE by novel stimuli is impacted. One-hundred fifty-one adolescents participated in the Novelty Task while undergoing functional magnetic resonance imaging (fMRI). In this task, participants learn to choose novel or non-novel stimuli to gain monetary reward. Level of AUD symptomatology was negatively associated with both optimal decision-making and BOLD response modulation by RPE within striatum and regions of prefrontal cortex. The neural alterations in RPE representation were particularly pronounced when participants were exploring novel stimuli. Level of CUD symptomatology moderated the relationship between novelty propensity and RPE representation within inferior parietal lobule and dorsomedial prefrontal cortex. These data expand on an emerging literature investigating individual associations of AUD symptomatology levels versus CUD symptomatology levels and RPE representation during reinforcement processing and provide insight on the role of neuro-computational processes underlying reinforcement learning/decision-making in adolescents.en-USAttribution 4.0 InternationalAdolescentAlcohol use disorderComputational modelingfMRIReward prediction errorStriatumArticle