Ragg, SusanneZehentner, Barbara K.Loken, Michael R.Croop, James M.2020-02-112020-02-112019-09Ragg, S., Zehentner, B. K., Loken, M. R., & Croop, J. M. (2019). Evidence for BCR/ABL1-positive T-cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell. Pediatric Blood & Cancer, 66(9), e27829. https://doi.org/10.1002/pbc.27829https://hdl.handle.net/1805/22050BCR‐ABL1‐positive leukemias have historically been classified as either chronic myelogenous leukemia or Ph+ acute lymphoblastic leukemia. Recent analyses suggest there may be a wider range of subtypes. We report a patient with BCR‐ABL1 fusion positive T‐cell ALL with a previously undescribed cell distribution of the fusion gene. The examination of sorted cells by fluorescence in situ hybridization showed the BCR‐ABL1 fusion in the malignant T cells and a subpopulation of the nonmalignant B cells, but not nonmalignant T cells or myeloid or CD34+ progenitor cells providing evidence that the fusion may have occurred in an early lymphoid progenitor.enPublisher PolicyBCR-ABL1discordant MRDT‐cell ALLArticle