Siddiqui, Mohammad S.Vuppalanchi, RajVan Natta, Mark L.Hallinan, ErinKowdley, Kris V.Abdelmalek, ManalNeuschwander-Tetri, Brent A.Loomba, RohitDasarathy, SrinivasanBrandman, DanielleDoo, EdwardTonascia, James A.Kleiner, David E.Chalasani, NagaSanyal, Arun J.2018-05-102018-05-102018Siddiqui, M. S., Vuppalanchi, R., Van Natta, M. L., Hallinan, E., Kowdley, K. V., Abdelmalek, M., … Sanyal, A. J. (2018). Vibration-controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2018.04.043https://hdl.handle.net/1805/16138Background & Aims Vibration-controlled transient elastography (VCTE), which measures liver stiffness, has become an important tool for evaluating patients with nonalcoholic fatty liver disease (NAFLD). We aimed to determine the diagnostic accuracy of VCTE in detection of NAFLD in a multicenter cohort of patients. Methods We performed a prospective study of 393 adults with NAFLD who underwent VCTE within 1 year of liver histology analysis (median time, 49 days; interquartile range, 25–78 days), from July 1, 2014 through July 31, 2017. Liver stiffness measurement (LSM) cutoffs for pairwise fibrosis stage and controlled attenuation parameter (CAP) cutoffs for pairwise steatosis grade were determined using cross-validated area under the receiver operating characteristics curve (AUROC) analyses. Diagnostic statistics were computed at sensitivity fixed at 90% and specificity fixed at 90%. Results LSM identified patients with advanced fibrosis with an AUROC of 0.83 (95% CI, 0.79– 0.87) and patients with cirrhosis with an AUROC of 0.93 (95% CI, 0.90–0.97). At fixed sensitivity, a cutoff LSM of 6.5 kPa excluded advanced fibrosis with a negative predictive value of 0.91; a cut-off LSM of 12.1 kPa excluded cirrhosis with a negative predictive value of 0.99. At fixed specificity, LSM identified patients with advanced fibrosis with a positive predictive 0.71 and patients with cirrhosis with a positive predictive value of 0.41. CAP analysis detected steatosis with an AUROC of 0.76 (95% CI, 0.64–0.87). In contrast, the VCTE was less accurate in distinguishing lower fibrosis stages, higher steatosis grades, or presence of NASH. Conclusion In a prospective study of adults with NAFLD, we found VCTE to accurately distinguish advanced vs earlier stages of fibrosis, using liver histology as the reference standard.enPublisher Policyfibroscanvibration controlled transient elastographycontrolled attenuation parameterArticle