Khan, Sikandar H.Lindroth, HeidiHendrie, KyleWang, SophiaImran, SundusPerkins, Anthony J.Gao, SujuanVahidy, Farhaan S.Boustani, MalazKhan, Babar A.2023-03-132023-03-132020Khan SH, Lindroth H, Hendrie K, et al. Time trends of delirium rates in the intensive care unit. Heart Lung. 2020;49(5):572-577. doi:10.1016/j.hrtlng.2020.03.006https://hdl.handle.net/1805/31853Background: Effects of clinical practice changes on ICU delirium are not well understood. Objectives: Determine ICU delirium rates over time. Methods: Data from a previously described screening cohort of the Pharmacological Management of Delirium trial was analyzed. Richmond Agitation-Sedation Scale (RASS) and Confusion Assessment Method for the ICU (CAM-ICU) were assessed twice daily. We defined: Any delirium (positive CAM-ICU at any time during ICU stay) and ICU-acquired delirium (1st CAM-ICU negative with a subsequent positive CAM-ICU). Mixed-effects logistic regression models were used to test for differences. Results: 2742 patient admissions were included. Delirium occurred in 16.5%, any delirium decreased [22.7% to 10.2% (p < 0.01)], and ICU-acquired delirium decreased [8.4% to 4.4% (p = 0.01)]. Coma decreased from 24% to 17.4% (p = 0.04). Later ICU years and higher mean RASS scores were associated with lower odds of delirium. Conclusions: Delirium rates were not explained by the measured variables and further prospective research is needed.en-USPublisher PolicyDeliriumTime trendIntensive care unitOutcomesArticle